The understanding of molecular mechanisms of SARS-Cov-2 is an urgent challenge to help the search of new drugs and preventive measures. Biosensors and degradable nanomaterials are novel approaches that could bring a rapid solution to the pandemic crisis.
Are nanoscale sensing tools efficient?
Nanodiagnostic systems for COVID-19 are gaining attention since they could be an interesting alternative to conventional diagnosis tests. However, the main challenge is to design a sensitive and rapid tool with regards to the long incubation period and high infectivity of the virus.
Status of nanodiagnostic systems for COVID-19 👉 Review
The role of biosensors and nanoscale analytical tools in pandemics 👉 Review
What about neutralizing the virus?
Neutralizing the virus in order to make it unable to infect cellular target is an alternative to drug development.
Zhang and collaborators (2020) report that cellular nanosponges will be able to neutralize the virus. These nanosponges are made of the plasma membranes derived from human lung epithelial type II cells or human macrophages.
Bhalla N., Pan Y., Yang Z., Payam A.F. ACS Nano Just Accepted Manuscript DOI: 10.1021/acsnano.0c04421
Sivasankarapillai, V.S., Pillai, A.M., Rahdar, A., Sobha, A.P., Das, S.S., Mitropoulos, A.C., Mokarrar, M.H., Kyzas, G.Z. Nanomaterials 2020, 10, 852.
Zhang Q., Honko A., Zhou J., Gong H., Downs S.N., Vasquez J.H., Fang R.H., Gao W., Griffiths A., Zhang L. Nano Letters Article ASAP DOI: 10.1021/acs.nanolett.0c02278